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影响因子：60.615

DOI码：10.1039/d3cs00565h

发表刊物：Chemical Society reviews

关键字：Photoacoustic Techniques/methods Contrast Media/chemistry Humans Animals Multimodal Imaging/methods Magnetic Resonance Imaging/methods

摘要：Optoacoustic (OA) imaging offers powerful capabilities for interrogating biological tissues with rich optical absorption contrast while maintaining high spatial resolution for deep tissue observations. The spectrally distinct absorption of visible and near-infrared photons by endogenous tissue chromophores facilitates extraction of diverse anatomic, functional, molecular, and metabolic information from living tissues across various scales, from organelles and cells to whole organs and organisms. The primarily blood-related contrast and limited penetration depth of OA imaging have fostered the development of multimodal approaches to fully exploit the unique advantages and complementarity of the method. We review the recent hybridization efforts, including multimodal combinations of OA with ultrasound, fluorescence, optical coherence tomography, Raman scattering microscopy and magnetic resonance imaging as well as ionizing methods, such as X-ray computed tomography, single-photon-emission computed tomography and positron emission tomography. Considering that most molecules absorb light across a broad range of the electromagnetic spectrum, the OA interrogations can be extended to a large number of exogenously administered small molecules, particulate agents, and genetically encoded labels. This unique property further makes contrast moieties used in other imaging modalities amenable for OA sensing.

合写作者：Dean-Ben, X L,Tang, L,Zhou, Q,Gezginer, I

第一作者：Chen, Z

论文类型：期刊论文

通讯作者：Razansky, D

卷号：53

期号：12

页面范围：6068-6099

ISSN号：1460-4744 (Electronic); 0306-0012 (Print); 0306-00

是否译文：否

发表时间：2024-06-17

收录刊物：SCI