Cortex-wide transcranial localization microscopy with fluorescently labeled red blood cells
Impact Factor:17.694
DOI number:10.1038/s41467-024-47892-3
Journal:Nature Communications
Key Words:Erythrocytes/metabolism/cytology Microscopy, Fluorescence/methods Mice Cerebral Cortex/blood supply/diagnostic imaging/metabolism Mice, Inbred C57BL Cerebral Angiography/methods Calcium/metabolism Cerebrovascular Circulation/physiology Fluorescent Dyes/chemistry Neurovascular Coupling/physiology Neurons/metabolism/physiology Microcirculation
Abstract:Large-scale imaging of brain activity with high spatio-temporal resolution is crucial for advancing our understanding of brain function. The existing neuroimaging techniques are largely limited by restricted field of view, slow imaging speed, or otherwise do not have the adequate spatial resolution to capture brain activities on a capillary and cellular level. To address these limitations, we introduce fluorescence localization microscopy aided with sparsely-labeled red blood cells for cor
Co-author:Tang, Lin,Glandorf, Lukas,Droux, Jeanne,El Amki, Mohamad,Wegener, Susanne,Weber, Bruno
First Author:Zhou, Quanyu,Glück, Chaim
Indexed by:Periodical papers
Correspondence Author:Razansky, Daniel,Chen, Zhenyue
Volume:15
Issue:1
Page Number:3526
ISSN No.:2041-1723
Translation or Not:no
Date of Publication:2024-04-25
Included Journals:SCI